These appear in professional writing constantly and are among the most noticed errors.

affect / effect

  • affect is usually a verb: "The delay affected our schedule."
  • effect is usually a noun: "The delay had an effect on our schedule."

Memory aid: Affect is an Action.

advice / advise

  • advice — noun, ends in an s sound: "She gave me good advice."
  • advise — verb, ends in a z sound: "I advise you to wait."

its / it's

  • its — possession: "The company changed its policy."
  • it's — it is / it has: "It's raining."

If you can expand it to "it is", use the apostrophe. Otherwise do not.

your / you're

Same test. "You're late" = "you are late". "Your bag" = belonging to you.

lose / loose

  • lose — to misplace or be defeated: "Don't lose the key."
  • loose — not tight: "The screw is loose."

then / than

  • then — time: "We ate, then we left."
  • than — comparison: "Bigger than before."

Words often mixed at work

  • assure (reassure a person) / ensure (make certain) / insure (buy insurance)
  • principal (main, or head of a school) / principle (a rule or belief)
  • stationary (not moving) / stationery (paper and pens)
  • complement (goes well with) / compliment (praise)
Spellcheck will not catch any of these, because both spellings are real words. They have to be known.